Major and minor histocompatibility antigens to NIMA
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چکیده
منابع مشابه
Major and Minor Histocompatibility Antigens to Non-Inherited Maternal Antigens (NIMA)
Immunological reactivity results from differences between the transplant host and donor for cell surface determinants known as histocompatibility antigens. Histocompatibility antigens that provoke the most severe transplant reactions are encoded by a series of genes that reside in a discrete chromosomal region termed the major histocompatibility complex (MHC) (Amos 1968). Genes of the human leu...
متن کاملMinor histocompatibility antigens.
ISTOCOMPATIBILITY antigens are a group of cell H membrane alloantigens that can trigger T-lymphocyte proliferative and/or cytolytic activity in vitro and may initiate graft rejection or graft-versus-host disease (GVHD) in vivo. AB0 and related antigens, whose presence on vascular endothelial cells may provoke antibody-mediated graft rejection, are excluded from this group because they do not in...
متن کاملHuman minor histocompatibility antigens.
Disparities in minor histocompatibility antigens between HLA-matched organ and bone marrow donors and recipients create a potential risk for graft failure and graft-versus-host disease. These conditions necessitate lifelong pharmacological immunosuppression of organ and bone marrow transplant recipients. Recent technical advances have resulted in the identification of the chemical nature of the...
متن کاملThe major histocompatibility complex determines susceptibility to cytotoxic T cells directed against minor histocompatibility antigens
Cytotoxic cells were generated by immunizing one strain of mouse with cells from an allogeneic strain which carries the same H-2 region. The effector cells assayed in a 4 h 51Cr release assay were shown to be T cells and indistinguishable, except in specificity, from cytotoxic T cells directed at H-2 alloantigens. Although the genetic differences between responder and stimulator cells responsib...
متن کاملFrequency of Major Histocompatibility Antigens Class I in Mazandaran Province
Background and purpose: Major histocompatibility antigens are the most polymorphic components of the immune system. The purpose of this study was to determine the frequency of human leukocyte antigens (HLA) in a population in Mazandaran province, Iran. Materials and methods: In a cross sectional study, peripheral blood samples were obtained from 550 people in Immunogenetics Research Center af...
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ژورنال
عنوان ژورنال: Chimerism
سال: 2011
ISSN: 1938-1956,1938-1964
DOI: 10.4161/chim.15127